Jason (Barts and the London Medical and Dental School, London, UK) Payne-James & Michael (United Kingdom and Ireland Association of Forensic Toxicologists, UK) Scott-Ham 
Symptoms and Signs of Substance Misuse 

The misuse of both legally prescribed and illegally supplied drugs is now so widespread that it affects, either directly or indirectly, a high proportion of the population, impacting many areas of daily life. There are few countries that are not touched by some aspect of substance misuse and the consequences for individuals, families and the wider