David J. Adelstein 
Squamous Cell Head and Neck Cancer 
Recent Clinical Progress and Prospects for the Future

Leading expert physicians and investigators from around the world review the state-of-the-art in the management of squamous cell head and neck cancer, with emphasis on coordinating different treatment modalities. The authors address several surgical issues, including laser-based surgery, larynx preservation approaches, salvage surgery, and neck management after non-operative treatment. They also discuss definitive radiation for larynx cancer, brachytherapy, altered fractionation radiation, intensity modulated radiation therapy, and the importance of tumor hypoxia, as well as the role of chemotherapy in sequential, concurrent, and adjuvant multi-modality treatment schedules. Other topics of special interest include targeted and gene therapies, multimodality management of nasopharyngeal cancer, chemoprevention, toxicity modification, quality of life outcomes, symptom palliation, and epidemiology.

Table des matières

Head and Neck Squamous Cell Cancers in the Nonsmoker-Nondrinker.- Laryngeal Preservation Surgery.- Laser Surgery for Head and Neck Cancer.- The Evolving Role of Neck Dissection in the Era of Organ Preservation Therapy for Head and Neck Squamous Cell Carcinoma.- Salvage Surgery After Chemoradiation Therapy.- T3–T4 Squamous Cell Carcinoma of the Larynx Treated With Radiation Therapy Alone or Combined With Adjuvant Chemotherapy.- Role of Brachytherapy in Treatment of Head and Neck Malignancy.- Intensity-Modulated Radiation Therapy in the Management of Head and Neck Cancer.- Altered Fractionation.- The Role of Tumor Hypoxia in Head and Neck Cancer Radiotherapy.- Induction Chemotherapy in Head and Neck Cancer.- The Evolution of Induction Chemotherapy in Locally Advanced Squamous Cell Cancer of the Head and Neck.- Concurrent Chemoradiotherapy.- Postoperative Treatment of Locally Advanced Head and Neck Cancers.- Multimodality Management of Nasopharyngeal Carcinoma.- Strategies for Protecting Normal Tissue in the Treatment of Head and Neck Cancer.- Targeted Therapies in Head and Neck Cancer.- Gene Therapy for Patients With Head and Neck Cancer.- Chemoprevention in Head and Neck Cancer.- Quality of Life Outcomes in Head and Neck Cancer.- Palliation of Head and Neck Cancer.