Daftar Isi
Preface: History of VGCCsSTRUCTURAL AND MOLECULAR ASPECTS OF VGCCS
1. Measuring and manipulating calcium
2. Structure, function and subunit assembly of VGCC3. Splice variation and RNA editing of VGCCs
4. Mechanisms of calcium channel permeation
5. Regulation by beta subunits6. Regulation by alpha2 delta subunits
7. VGCCs in invertebrates
REGULATION OF VGCCS
8. Modulation by GPCRs and second messengers
9. Trafficking of VGCCs
10. Calcium regulation
11. Calcium channel complexes with other channels
12. Regulation of gene transcription by VGCCs
(PATHO)PHYSIOLOGY OF VGCCS
13. Lessons from knock-out and knock-in mice
14. VGCCs and synaptic transmission
15. Cardiovascular syste
16. Calcium channels and exocytosis in chromaffin cells
17. Calcium channels in the pancreas in health and disease
18. Skeletal muscle system
19. Auditory and visual systems
20. Calcium channels and pain transmission
21. Migraine
22. Epilepsy
23. Psychiatric disorders
24. Parkinson’s disease
25. Reproductive system
26. Cancer
PHARMACOLOGY OF VGCCS
27. Molecular determinants of VGCC pharmacology
28. Interactions with peptide toxins
29. Clinical pharmacology and drug discovery
Tentang Penulis
Dr. Gerald Werner Zamponi is a Professor in the Department of Physiology and Biophysics, and Canada Research Chair in Molecular Neuroscience, at the University of Calgary, Calgary, Canada.
Dr. Norbert Weiss is an Assistant Professor in the Department of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic.