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David C Blakemore & Paul M Doyle 
Synthetic Methods in Drug Discovery 
Volume 1

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Synthetic Methods in Drug Discovery Volume 1 focusses on the hugely important area of transition metal mediated methods used in industry. Current methods of importance such as the Suzuki-Miyaura coupling, Buchwald-Hartwig couplings and CH activation are discussed. In addition, exciting emerging areas such as decarboxylative coupling, and the uses of iron and nickel in coupling reactions are also covered. This book provides both academic and industrial perspectives on some key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Edited and authored by leading scientists from both academia and industry, this book will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.

€229.99
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Jadual kandungan

Suzuki-Miyaura Coupling; Negishi Coupling; Hiyama Coupling; Sonogashira Coupling; Heck Coupling; Palladium- and Copper-Catalysed C–N Cross-Coupling in Drug Discovery; Chan-Lam Coupling Reaction; C−H Activation Approaches to Molecules; Palladium-Catalyzed Decarboxylative Couplings; New Frontiers with Transition Metals

Mengenai Pengarang

David Blakemore has spent his entire career in the pharmaceutical industry. Following his post-docs in Cambridge and Paris, he joined Warner-Lambert as a Group Leader in the Discovery Chemistry group.  In 2001, he joined Pfizer in Sandwich and is currently the Synthesis Lead for the World-Wide Medicinal Chemistry Group at Pfizer Neusentis. Part of David’s role is in liaising with academics to highlight key areas of chemistry that could be of real value to the pharmaceutical industry and to develop interactions in those areas.
Paul Doyle has spent his entire career at the interface of chemistry and biology in the service of drug discovery. After his first degree in chemistry at Oxford, Paul completed his D.Phil. at the University of Sussex studying bio-organic synthetic chemistry. He spent a 15-year early career in a wide variety of therapeutic discovery programmes at the Wellcome Foundation before establishing one of the first UK discovery CROs, Biofocus. In 2008, Paul joined Peakdale as CEO.
Yvette Fobian has spent the majority of her career in the pharmaceutical industry. After completing her Ph D and spending a year in Monsanto’s Corporate Research, she joined the Medicinal Chemistry Group in Searle/Monsanto in 1997 and ultimately Pfizer in 2003 following a series of mergers and acquisitions. In her most current role, Yvette is in an excellent position to see first-hand the needs and impact of synthetic enablement for both small and large scale delivery within the discovery team.
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Bahasa Inggeris ● Format PDF ● Halaman-halaman 455 ● ISBN 9781782622086 ● Saiz fail 16.5 MB ● Penyunting David C Blakemore & Paul M Doyle ● Penerbit Royal Society of Chemistry ● Diterbitkan 2016 ● Edisi 1 ● Muat turun 24 bulan ● Mata wang EUR ● ID 4960363 ● Salin perlindungan Adobe DRM
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