Fazlul H. Sarkar 
MicroRNA Targeted Cancer Therapy 

Since the discovery of micro RNAs (mi RNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of mi RNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered mi RNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of mi RNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of mi RNAs or small non-coding RNAs could also regulate the expression of genes and likewise, mi RNA genes are also regulated by transcription factors. The most attractive feature of mi RNAs is that one mi RNA can regulate many target genes (m RNAs) and thus mi RNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single mi RNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, mi RNA targeted therapy is an attractive attribute of mi RNA research, which is covered through eighteen chapters complied in this book “Micro RNA targeted Cancer therapy” and it is hoped that the field of mi RNA research will be appreciated through critical reading of these chapters on the cutting-edge research on mi RNAs.

Jadual kandungan

Preface

1             The therapeutic role of micro RNAs in human gliomas

2             mi RNA expression and functions in glioma and glioma stem cells

3             The role of mi RNAs in lung cancer drug resistance and targeted therapy

4             The Potential Role of Micro RNA-Based Therapy for Lung Cancer Stem Cells

5             State of our knowledge on mi RNA targeted therapy in Lung Cancer

6             mi RNA-based Ovarian Cancer Diagnosis and Therapy

7             Application of micro RNA in the treatment and diagnosis of cervical cancer

8             Overcoming Drug Resistance in Colorectal Cancer by micro RNAs

9             Micro RNAs as novel targets in liver cancer- facing the clinical challenge

10           Micro RNA based therapeutic strategies for cancer: Emphasis on advances in renal cell carcinoma.

11           Modulating micro RNA expression for the therapy of pancreatic cancer

12           Micro RNA targeted therapy for overcoming drug resistance, reversal of EMT and elimination of cancer stem cells in prostate and pancreatic cancer

13           Modulation of deregulated mi RNAs for targeted therapy in thyroid cancer

14             mi RNA-targeted therapies in the most prevalent pediatric solid tumors

15           Targeting Immune System Through Targeting mi RNA For Cancer Therapy

16           mi RNA regulation of DNA damage repair proteins in cancer cells: interplay of ATM, TRAIL and mi RNA

17           mi RNA regulation of VEGF/VEGFR signaling

18           Systems Biology Approaches in the Design of Effective mi RNA-Targeted Therapeutics

Index