Harold C. Smith 
RNA and DNA Editing 
Molecular Mechanisms and Their Integration into Biological Systems

RNA and DNA Editing assembles a team of leading experts who present the latest discoveries in the field alongside the latest models and methodology. In addition, the authors set forth the many open questions and suggest routes for further investigation. Overall, the book serves as a practical guide for professionals in the field who need to understand the interrelationship of RNA and DNA editing with other chemical and biological processes.

Cuprins

Preface.

Acknowledgements.

Contributors.

Part I: Diversification of the Proteome through RNA and DNA
Editing.

Chapter 1. Diversifying Exon Code Through A-To-I RNA
Editing.

Chapter 2. Antibody Gene Diversification by Aid-Catalyzed DNA
Editing.

Chapter 3. Protein-Protein and RNA-Protein Interactions in
U-Insertion/Deletion RNA Editing Complexes.

Chapter 4. Machinery of RNA editing in Plant Organelles.

Part II: Functional Coordination of RNA Editing With Other
Cellular Mechanisms.

Chapter 5. Transfer RNA Editing Enzymes: At the Crossroads of
Affinity and Specificity.

Chapter 6. A-To-I Editing as a Co-Transcriptional RNA Processing
Event.

Chapter 7. Studying and Working with Ribonucleoproteins that
Catalyze H/ACA Guided RNA Modification.

Chapter 8. Functional Roles of Spliceosomal SNRNA
Modifications in Pre-m RNA Splicing.

Chapter 9. A Role for A-To-I Editing in Gene Silencing.

Chapter 10. biological Implications and Broader-Range Functions
For Apobec-1 and Apobec-1 Complementation Factors (ACF)

Chapter 11. Antiviral Function of APOEC3 Cytidine
Deaminases.

Part III: Predictive Structures.

Chapter 12. A-To-I Editing of ALU Repeats.

Chapter 13. RNA Editing in Dinoflagellates and Implications for
the Evolutionary History of the Editing Machinery.

Part IV: Structural Approaches.

Chapter 14. The Box C/D RNPs: Evolutionarily Ancient Nucleotide
Modification Complexes.

Chapter 15. Structural Features of the Adar Family of Enzymes
and Their Substrates.

Chapter 16. Chemistry, Phylogeny, and three-Dimensional
Structure of the Apobec Protein Family.

Index.

Despre autor

Harold C. Smith, Ph D, is Professor in the Department of Biochemistry and Biophysics at the University of Rochester and the founder and Chief Scientific Officerof Oya Gen, a biotech company that develops drugs that target editing enzymes. Dr. Smith organized the first Gordon Research Conference on RNA Editing in 1997 and holds four patents.