Yu Mei 
Functional Characterization of Arabidopsis Phosphatidylinositol Monophosphate 5-kinase 2 in Lateral Root Development, Gravitropism and Salt Tolerance 

The functional characterization of a key enzyme in the phosphatidylinositol (PI) signaling pathway in the model plant Arabidopsis thaliana is the focus of the research summarised in this thesis. Moreover, a particular focus is the exploration of the biological functions of Arabidopsis phophatidylinositol monophosphate 5-kinase 2 (PIP5K2) which catalyzes the synthesis of phophatidylinositol (4, 5) bisphosphate, the precursor of two important second messengers (inositol 1, 4, 5-trisphosphate and diacylglycerol). Through molecular and genetic approaches, the author isolated and characterized the expression pattern, physiological functions and the underlying mechanism of Arabidopsis PIP5K2. It is found that PIP5K2 is involved in regulating lateral root formation and root gravity response through modulating auxin accumulation and polar auxin transport and also plays a critical role in salt tolerance. These findings shed new light on the crosstalk between PI signaling and auxin response, both of which have crucial regulatory roles in plant development.

Cuprins

​Review of phosphatidylinositol phosphate kinase in phosphatidylinositol signaling pathway.- Structure and expression pattern analysis of Arabidopsis PIP5K2.- Arabidopsis PIP5K2 is involved in lateral root development through regulating auxin accumulation.- Arabidopsis PIP5K2 is involved in root gravitropism through regualtion of auxin polar transport.- Arabidopsis PIP5K2 is involved in salt tolerance​ ​

Despre autor

Yu Mei obtained her Ph.D. from Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Science (CAS). She was supervised by Prof. Hongwei Xue, who is an outstanding research in plant science. During her Ph.D. study, Dr. Mei did a systematical study on PIP5K2 and published two first-authored research articles on top journals in this field. She received the excellent doctoral dissertation of CAS in 2013. Dr. Mei is now a post-doctor at Iowa State University.