Lowell T. Duncan 
Advances in Health and Disease. Volume 34 

This volume presents eight chapters, each focused on a particular topic in health and disease. Chapter One reviews the mechanism of action and clinical evidence available on the effect of sodium-glucose co-transporter 2 inhibitors (SGLT2i) on glycemic control, weight, blood pressure, and cardiovascular and renal outcomes in patients with type 2 diabetes. Chapter Two explains the diagnosis and management of bruxism, a disorder defined by the repetitive involuntary activity of muscles of mastication characterized by teeth clenching or grinding. Chapter Three details the diagnosis and treatment options for acute appendicitis. Chapter Four focuses on the evolution of pharmacological management of gastroesophageal reflux disease (GERD) with a focus on the current updates in terms of the safety and efficacy of acid suppressive therapy (AST). Chapter Five explores the profile of pediatric patients with bruxism following a therapeutic care program in a health center specialized in bruxism during childhood. Chapter Six discusses the role of anti-reflux surgery in GERD, which is used in cases where AST fails to treat the disease. Chapter Seven provides another perspective on the diagnosis and management of acute appendicitis. Finally, Chapter Eight focuses on the diagnosis of GERD, as well as its medical, endoscopic and surgical management.